Adiponectin and Coronary Heart Disease
Key result
Higher circulating adiponectin concentrations were not significantly associated with a reduced risk of coronary heart disease compared to lower concentrations (OR 0.89; 95% CI 0.67-1.18).
Why the study?
Are higher circulating adiponectin concentrations associated with a reduced risk of coronary heart disease?
Population
589 men with fatal CHD or nonfatal myocardial infarction and 1231 controls nested within a prospective study…
Comparison
High circulating adiponectin concentrations vs Low circulating adiponectin concentrations
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
No CHD risk reduction from higher adiponectin; confirms prior conflicting data and contrasts with its strong type 2 diabetes association.
Study Design
Type
Case-Control (n=1,820)
Structured PICO
Are higher circulating adiponectin concentrations associated with a reduced risk of coronary heart disease?
P
Population
589 men with fatal CHD or nonfatal myocardial infarction and 1231 controls nested within a prospective study of 5661 men (aged 40 to 59 years), along with a meta-analysis of 7 prospective studies involving a total of 1318 CHD cases.
I
Intervention
High circulating adiponectin concentrations (top third)
C
Comparator
Low circulating adiponectin concentrations (bottom third)
O
Outcome
Coronary heart disease (fatal CHD or nonfatal myocardial infarction)hard clinical
Main Result
Effect estimate: OR 0.89 (95% CI 0.67-1.18)
Circulating adiponectin levels have only a moderate, non-significant inverse association with coronary heart disease risk, contrasting with their strong association with type 2 diabetes.
Cite This Study
Sattar et al. (2006) conducted a case-control in Coronary heart disease (n=1,820). Top third of adiponectin concentrations vs. Bottom third of adiponectin concentrations was evaluated on Fatal coronary heart disease or nonfatal myocardial infarction (OR 0.89, 95% CI 0.67-1.18). Higher circulating adiponectin concentrations were not significantly associated with a reduced risk of coronary heart disease compared to lower concentrations (OR 0.89; 95% CI 0.67-1.18).