Adiponectin and Risk of Coronary Heart Disease in Older Men and Women
Key result
High adiponectin concentrations (quintile 5 vs. 1-4) were associated with an increased risk of incident coronary heart disease in older adults (OR 1.37; 95% CI 1.02-1.84).
Why the study?
Are high adiponectin concentrations associated with an increased risk of incident CHD in older adults?
Population
1,386 older men and women from the population-based Cardiovascular Health Study
Comparison
High adiponectin concentrations (quintile 5) vs Lower adiponectin concentrations (quintiles 1-4)
Design
Case-control
Follow-up
1992-2001
Authors
Discussion
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Member takes
Implication
Should not change clinical risk assessment; leaves open causality and needs prospective confirmation.
Study Design
Type
Case-Control (n=1,386)
Multicenter
Yes
Structured PICO
Are high adiponectin concentrations associated with an increased risk of incident CHD in older adults?
P
Population
1,386 older adults from the Cardiovascular Health Study evaluated in a nested case-control design to assess the relationship between adiponectin and incident coronary heart disease.
E
Exposure
High adiponectin concentrations (quintile 5)
C
Comparator
Lower adiponectin concentrations (quintiles 1-4)
O
Outcome
Incident CHD defined as angina pectoris, percutaneous or surgical revascularization, nonfatal myocardial infarction (MI), or CHD deathcomposite
Main Result
Odds Ratio: 1.37 (95% CI 1.02–1.84)
High adiponectin concentrations are associated with an increased risk of first-ever coronary heart disease in older adults, despite its known insulin-sensitizing properties.
Cite This Study
Kizer et al. (2008) conducted a case-control in Coronary Heart Disease (n=1,386). High adiponectin concentrations (quintile 5) vs. Lower adiponectin concentrations (quintiles 1-4) was evaluated on Incident CHD (angina pectoris, percutaneous or surgical revascularization, nonfatal MI, or CHD death) (OR 1.37, 95% CI 1.02-1.84). High adiponectin concentrations (quintile 5 vs. 1-4) were associated with an increased risk of incident coronary heart disease in older adults (OR 1.37; 95% CI 1.02-1.84).