Key result
Adiponectin levels in the highest sex-specific quintile were associated with an almost 40% increased risk of cardiovascular disease death and all-cause mortality over 20 years (P<0.001).
Why the study?
Do higher adiponectin levels predict reduced risk of coronary heart disease and mortality in community-dwelling older adults?
Population
1,513 community-dwelling men and women aged 50-91 years
Comparison
High adiponectin levels vs Low adiponectin levels
Design
Cohort
Follow-up
20 years (from 1984-1987 through 2004)
Authors
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High adiponectin levels should not yet inform cardiovascular risk stratification in older adults; leaves open its paradoxical role pending causal studies.
Cohort (n=1,513)
Do higher adiponectin levels predict reduced risk of coronary heart disease and mortality in community-dwelling older adults?
Effect estimate: 40% increased risk
p-value: p=<0.001
High adiponectin levels are paradoxically associated with increased risks of cardiovascular and all-cause mortality, suggesting its use for cardiovascular disease risk stratification is premature.
Laughlin et al. (2006) conducted a cohort in Coronary heart disease and mortality (n=1,513). Adiponectin levels vs. Lower levels was evaluated on Cardiovascular disease death and death from all causes (40% increased risk, p=<0.001). Adiponectin levels in the highest sex-specific quintile were associated with an almost 40% increased risk of cardiovascular disease death and all-cause mortality over 20 years (P<0.001).
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