Plasma Adiponectin Levels Are Associated with Insulin Resistance, But Do Not Predict Future Risk of Coronary Heart Disease in Women
Why the study?
Do plasma adiponectin levels predict future risk of incident coronary heart disease in women?
Population
501 women aged 60-79 years at baseline, nested within the 4286 women in the British Women's Heart and Health…
Design
Case-control
Follow-up
4 years
Authors
Discussion
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Member takes
Implication
Adiponectin should not guide CHD risk assessment in women; leaves open its value in other populations or multimarker models.
Key Points
- To assess whether circulating adiponectin levels predict the prospective risk of incident coronary heart disease in older women.
- Conducted a 4-year prospective nested case-control study within the British Women's Heart and Health Study across 23 British towns in a primary care setting.
- Analyzed baseline plasma samples from 167 incident coronary heart disease cases and 334 controls selected from a cohort of 4,286 women aged 60–79 years.
- Adiponectin levels correlated positively with age and high-density lipoprotein cholesterol, and inversely with waist-to-hip ratio, fasting insulin, fasting glucose, homeostasis model assessment scores, C-reactive protein, and triglycerides.
- Plasma adiponectin did not predict incident coronary heart disease events in either unadjusted or adjusted analyses, yielding a relative risk ratio of 0.93 (95% CI, 0.78 to 1.11) per doubling of concentration.
Structured PICO
Do plasma adiponectin levels predict future risk of incident coronary heart disease in women?
P
Population
501 women (167 cases, 334 controls) aged 60-79 years at baseline, nested within the 4286 women in the British Women's Heart and Health Study.
I
Intervention
Plasma adiponectin levels
O
Outcome
Incident coronary heart disease (CHD) events and association with CHD risk factorshard clinical
Plasma adiponectin levels are associated with insulin resistance but do not independently predict future risk of coronary heart disease in women.
Cite This Study
Lawlor et al. (2005) studied this question.