Key result
Stillbirth and recurrent miscarriage (>3) were associated with a higher risk of myocardial infarction (fully adjusted HR 2.32, 95% CI 1.19-4.50 and HR 5.06, 95% CI 1.26-20.29, respectively).
Why the study?
Does pregnancy loss increase the risk of myocardial infarction and stroke in women?
Population
11,518 women who had ever been pregnant (aged 35-66) from the EPIC cohort in Heidelberg, Germany.
Comparison
Pregnancy loss vs No pregnancy loss (implied reference group)
Design
Cohort
Follow-up
mean 10.8 years
Authors
Loading...
May warrant considering recurrent pregnancy loss in women's MI risk assessment; hypothesis-generating for sex-specific predictors.
Cohort (n=11,518)
No
Does pregnancy loss increase the risk of myocardial infarction and stroke in women?
Hazard Ratio: 2.32 (95% CI 1.19–4.5)
Spontaneous pregnancy loss, particularly recurrent miscarriage and stillbirth, is a strong sex-specific predictor for future myocardial infarction in women.
Kharazmi et al. (2010) conducted a cohort in Pregnancy loss (n=11,518). Stillbirth vs. No stillbirth was evaluated on Myocardial infarction (HR 2.32, 95% CI 1.19-4.50). Stillbirth and recurrent miscarriage (>3) were associated with a higher risk of myocardial infarction (fully adjusted HR 2.32, 95% CI 1.19-4.50 and HR 5.06, 95% CI 1.26-20.29, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: