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ABSTRACT The rise of multidrug‐resistant (MDR) bacteria poses a significant threat to global health, prompting the need for alternative antimicrobial agents and strategies. In this study, we report the synthesis and antibacterial evaluation of a novel zinc‐based metal–organic framework (Zn‐MOF) exhibiting broad‐spectrum activity. The structural and physicochemical properties of the Zn‐MOF were comprehensively characterized, offering detailed insight into its molecular framework, crystalline features, surface characteristics, and overall morphology. Antibacterial performance was assessed against Gram‐positive Staphylococcus aureus (ATCC 6538) and Gram‐negative MDR carbapenem‐resistant Acinetobacter baumannii through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. The results revealed strong inhibitory effects against both bacterial strains, with MIC values (625 µg/mL). Mechanistic investigations revealed that the Zn‐MOF exert their antibacterial activity through simultaneous disruption of the bacterial cell membrane integrity, evidenced by protein, nucleic acid, and potassium ion leakage, alongside the induction of intracellular reactive oxygen species (ROS). Together, these effects confirm a multi‐targeted bactericidal mechanism. Overall, this study highlights the strong antibacterial efficacy of Zn‐MOF against MDR pathogen and underscores their potential as a promising strategy for addressing the growing challenge of antimicrobial resistance.
Hassan et al. (Wed,) studied this question.