Key result
Mitochondrial oxidative stress is a major therapeutic target for myocardial remodeling, and systematic disease management is crucial to reduce high readmission rates in real-world heart failure patients.
This review highlights the dual importance of targeting mitochondrial oxidative stress in basic research and implementing comprehensive disease management programs in clinical practice to improve heart failure outcomes.
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Should not change HF practice; leaves open whether mitochondrial targeting improves outcomes in trials.
Hiroyuki Tsutsui (2004) conducted a review in Heart failure. Mitochondrial oxidative stress is a major therapeutic target for myocardial remodeling, and systematic disease management is crucial to reduce high readmission rates in real-world heart failure patients.
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