What question did this study set out to answer?

To evaluate phenomenological and molecular evidence for homeostatic regulation in the nervous system and extract general design principles from simplified biological systems.

April 7, 2006Annual Review of Neuroscience

HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design

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Authors

GDGraeme W. DavisUniversity of California, San Francisco

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Implication

Systematic review uncovers molecular mechanisms regulating neural excitability and synaptic efficacy, highlighting principles that stabilize nervous system function over time.

Key Points

To evaluate phenomenological and molecular evidence for homeostatic regulation in the nervous system and extract general design principles from simplified biological systems.
Reviewed theoretical and experimental evidence of homeostatic signaling regulating synaptic efficacy and membrane excitability under a rigorous definition of homeostasis.
Analyzed well-characterized feedback control systems in non-neural models, including bacterial chemotaxis and the heat shock response, to identify conserved molecular implementation strategies.
Homeostatic signaling stabilizes neural circuits by constraining runaway plasticity through negative feedback adjustments in synaptic strength and intrinsic membrane excitability.
Core regulatory motifs from non-neural systems, such as integral feedback and robust set-point maintenance, provide a viable framework for understanding complex neural stabilization mechanisms.

Cite This Study

Graeme W. Davis (2006) studied this question.

synapsesocial.com/papers/6a6599bdf3bdf71dcbd69d79 https://doi.org/10.1146/annurev.neuro.28.061604.135751

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Implication

Systematic review uncovers molecular mechanisms regulating neural excitability and synaptic efficacy, highlighting principles that stabilize nervous system function over time.

HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design

Discussion

Member takes

Implication

Key Points

Cite This Study

HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design

Discussion

Member takes

Implication

Key Points

Cite This Study

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