By introducing a photolabile group in the Watson–Crick base-pairing site of a guanosine residue, a bistable 20-base RNA sequence was forced into a less stable conformation. A single laser pulse released the native sequence, and the subsequent refolding equilibration was monitored with time-resolved NMR spectroscopy (see spectra). This permitted a quantitative description of the refolding process.
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Wenter et al. (2005) studied this question.
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