Key result
ATP applied at a micromolar range activates a native TREK-1-like K+ current in rat ventricular cardiomyocytes via a dual-MAPK cytosolic pathway involving p38 MAPK and p42/44 MAPK.
Population
Rat ventricular cardiomyocytes isolated from Wistar rats
Comparison
ATP (purine agonist) applied at a micromolar range vs Control conditions and presence of various…
Design
Preclinical
Authors
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ATP-sensitive TREK-1-like current identified in rat myocytes; leaves open its role in human ventricular electrophysiology.
This study provides the first characterization of a native TREK-1-like potassium current in cardiac cells that is activated by ATP via a dual-MAPK cytosolic pathway.
Aimond et al. (2000) studied this question. ATP was evaluated on Activation of TREK-1-like current (ITREK). ATP applied at a micromolar range activates a native TREK-1-like K+ current in rat ventricular cardiomyocytes via a dual-MAPK cytosolic pathway involving p38 MAPK and p42/44 MAPK.
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