Key result
AGTR1 and ABCB1 gene polymorphisms showed no significant overall effect on blood pressure change following irbesartan administration, though differences emerged at irbesartan levels >300 ng/mL.
Why the study?
Interindividual heterogeneity in antihypertensive response to irbesartan has been linked to gene polymorphism, prompting investigation into the combinational influences of AGTR1 and ABCB1 polymorphisms in Chinese hypertensive patients.
Do AGTR1 and ABCB1 gene polymorphisms influence blood pressure change following irbesartan administration in Chinese hypertensive patients?
Observational (n=353)
Do AGTR1 and ABCB1 gene polymorphisms influence blood pressure change following irbesartan administration in Chinese hypertensive patients?
ABCB1 gene polymorphisms may influence the blood pressure response to irbesartan at higher doses (>300 ng/mL) in Chinese patients.
ABCB1 variants may influence irbesartan response at high doses; hypothesis-generating and should not yet change practice.
The interindividual heterogeneity in response to the antihypertensive effect of irbesartan has received considerable attention because of gene polymorphism. In this study, we investigated the new combinational influences of AGTR1 and ABCB1 gene polymorphism on the therapeutic effect of irbesartan among Chinese hypertensive patients. A total of 353 samples including 168 normal people and 185 hypertensive patients were adopted, and genotypes comprise ABCB1 (CC, CT, and TT) and AGTR1 (AA and AC) in this study. The results of multiple linear regression models showed that no statistically significant differences were observed in blood pressure change following irbesartan administration in each genotype from either ABCB1 (CC, CT, and TT) or AGTR1 (AA and AC). However, spline smoothing analysis demonstrated that the blood pressure therapeutic responses of irbesartan presented a noticeable difference among different ABCB1 genotypes when irbesartan doses reached over 300 ng/mL. Eventually, we assumed that the different drug responses of irbesartan among various AGTR1 genotypes were due to the diversity of the irbesartan-conjugated protein, which is responsible for crossing-coupled intracellular G-protein-coupled receptors (GPCRs).
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Wang et al. (2022) conducted an observational in Hypertension (n=353). AGTR1 and ABCB1 gene polymorphisms vs. Different genotypes was evaluated on Blood pressure change following irbesartan administration. AGTR1 and ABCB1 gene polymorphisms showed no significant overall effect on blood pressure change following irbesartan administration, though differences emerged at irbesartan levels >300 ng/mL.
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