Why the study?
Does the AT1R gene polymorphism influence the relationship between plasma irbesartan concentration and blood pressure response in patients with hypertension and left ventricular hypertrophy?
Population
42 patients with mild-to-moderate hypertension and left ventricular hypertrophy from the Swedish Irbesartan…
Design
Cohort
Follow-up
12 weeks
Authors
Loading...
AT1R C5245T may modify irbesartan concentration-response; hypothesis-generating in LVH hypertension and requires validation.
Does the AT1R gene polymorphism influence the relationship between plasma irbesartan concentration and blood pressure response in patients with hypertension and left ventricular hypertrophy?
This study suggests that the concentration-response relationship of irbesartan in reducing blood pressure may be dependent on the AT1R C5245T genotype.
Kurland et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: