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This study aims to explore the effects of MitoQ, an antioxidant, on hyperpermeability in acute lung injury and the underlying mechanisms.

March 7, 2021Redox BiologyOpen Access

MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism

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This study aims to explore the effects of MitoQ, an antioxidant, on hyperpermeability in acute lung injury and the underlying mechanisms.
Investigated MitoQ treatment effects on ALI in mice via intraperitoneal injection and in vitro studies on human pulmonary microvascular endothelial cells.
Performed RNA sequencing to evaluate gene expression changes in endothelial cells after MitoQ treatment.
MitoQ significantly reduced excessive reactive oxygen species (ROS) and apoptosis in endothelial cells (p<0.05).
Increased nuclear translocation of Nrf2 and upregulated downstream antioxidant response elements (AREs) were observed in MitoQ treated groups.
Nrf2 deficient mice showed diminished protective effects of MitoQ against ALI.

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Randomized trial shows MitoQ reverses endothelial disruption in acute lung injury, suggesting its potential as a treatment.

Cen et al. (2021) studied this question.

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