Tailors at work: The structurally intriguing thiopeptide antibiotic natural products have been conclusively and universally shown to be biosynthesized from genetically encoded linear precursor peptides by novel tailoring enzymes. These unique findings challenge previously accepted biosynthesis paradigms and are expected to inspire future discoveries in the chemistry and biology of peptide natural products.
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Arndt et al. (2009) studied this question.
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