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July 26, 2026Dermatology and TherapyOpen Access

Six-Month Changes in Periorbital and Perioral Wrinkles and Facial Skin Quality following Low-Cross-Linked Hyaluronic Acid

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Authors

KYKyu‐Ho YiYPYerin ParkJLJiyeon Lee

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Overview

Observational study shows improvement in facial wrinkles and skin quality in subjects after treatment.

Key Points

  • The aim was to evaluate the efficacy and safety of low-cross-linked hyaluronic acid for fine wrinkles.
  • 25 subjects with WSRS ≥ 2 received three intradermal microinjections at 4-week intervals.
  • Follow-up assessments for 24 weeks to measure efficacy, durability, and safety.
  • Outcomes included wrinkle severity, aesthetic improvement, skin quality parameters, and ultrasound measurements.
  • Mean WSRS scores decreased significantly from 3.06 to 1.79 in the periorbital area and from 3.18 to 2.01 in the perioral area.
  • 81.8% of subjects showed global aesthetic improvement by investigator assessment.
  • Significant changes in skin elasticity, hydration indices, and increased dermal thickness observed.

Cite This Study

Yi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a2e2d3aea3239cd7636ehttps://doi.org/10.1007/s13555-026-01854-3
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