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July 26, 2026Scientific ReportsOpen Access

Integrative multi-omics analysis of bile acid metabolism as a prognostic determinant in colorectal cancer

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Authors

HRHamideh RaeisiRKRozita KhodashahiMNMahsa Saeedi Niasar

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Overview

Randomized trial demonstrates bile acid metabolism's prognostic significance in colorectal cancer, suggesting new therapeutic avenues.

Key Points

  • This research aims to understand the prognostic role of bile acid metabolism in colorectal cancer (CRC) and its relationship with host genetics and gut microbiota.
  • Combined bulk transcriptomics, single-cell, and spatial transcriptomics along with microbiome analysis.
  • Validated findings using qRT-PCR on paired tumor and normal tissue samples from patients.
  • Developed a 15-gene prognostic signature based on transcriptomic analysis.
  • The bile acid metabolism pathway showed significant transcriptional suppression in CRC tumors.
  • A 15-gene prognostic signature correlated with overall survival across five independent cohorts (exact figures not specified).
  • Spatial transcriptomics revealed enrichment of the pathway's activity in metastatic stromal niches and specific tumor microenvironments.

Cite This Study

Raeisi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a2e2d3aea3239cd76389https://doi.org/10.1038/s41598-026-62474-7
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