What question did this study set out to answer?

This research aims to understand how the Oprm1 A118G variant affects cellular and molecular responses to opioid dependence in mice.

July 26, 2026Nature CommunicationsOpen Access

Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G

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Authors

YXYihan XieZhejiang Wanli University ALAnna K. Leonard OGOmar Guessoum

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Implication

Randomized trial reveals distinct cellular changes in opioid dependence among female mice with genetic variants, indicating the influence of genetic risk on brain function.

Key Points

This research aims to understand how the Oprm1 A118G variant affects cellular and molecular responses to opioid dependence in mice.
Single-nucleus spatial transcriptomic analyses were performed on Oprm1 A112G mice with and without morphine dependence.
Cell type composition and transcriptional changes were assessed in response to opioid exposure.
Cellular responses were linked to genetic variations in opioid receptors.
Opioid dependence caused significant transcriptomic changes in glial populations in Oprm1 GG mice, not in neurons.
The Oprm1 risk allele (G) was associated with glial alterations, while the protective allele (A) correlated with neuronal plasticity.
Molecular pathways governing opioid dependence were mapped, linking genetic risk to functional changes in the brain.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/6a65a2e2d3aea3239cd7639e https://doi.org/10.1038/s41467-026-75723-0

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Implication

Randomized trial reveals distinct cellular changes in opioid dependence among female mice with genetic variants, indicating the influence of genetic risk on brain function.

Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G

Discussion

Member takes

Implication

Key Points

Cite This Study

Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G

Discussion

Member takes

Implication

Key Points

Cite This Study

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