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July 23, 2026CancersOpen Access

Management of Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus: Current Evidence and Future Perspectives—A Narrative Review

Hiroyuki Kato Zenichi Morise Yutaro Kato Hidetoshi Katsuno Masahiro Ito Akihiko Horiguchi

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Key Points

This review aims to evaluate the impact of portal vein tumor thrombus in hepatocellular carcinoma and explore management strategies.
Review of existing literature on management practices for HCC with PVTT.
Analysis of current evidence and treatment outcomes.
Discussion of future perspectives and potential therapeutic advances.
Portal vein tumor thrombus significantly worsens prognosis in patients with HCC.
Current management options include surgical resection and transarterial chemoembolization, with varying success rates.
Emerging treatment modalities and personalized approaches show promise for improving outcomes in these patients.

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Implication

Narrative review examines current evidence and future strategies for managing HCC with PVTT, suggesting new approaches.

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Cite This Study

Kato et al. (2026) studied this question.

synapsesocial.com/papers/6a65a306d3aea3239cd7655d https://doi.org/10.3390/cancers18152380

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