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July 23, 2026Clinical Oral InvestigationsOpen Access

Impact of Aggregatibacter actinomycetemcomitans on inflammasome regulation and epigenetic changes in grade C periodontitis

Aurélio Amorim Reis Hélvis E. S. Paz Catharina Marques Sacramento Karina Gonzáles Silvério Enílson Antônio Sallum Mabelle Freitas Monteiro Renato Côrrea Viana Casarin Camila S. Stolf

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Key Points

This study aims to evaluate the impact of Aggregatibacter actinomycetemcomitans on inflammasome gene expression and epigenetic changes in periodontitis.
Primary gingival fibroblasts from healthy individuals and Grade C periodontitis patients were exposed to AaPE (5 µg/ml) for 1.5 hours.
Gene expression was analyzed via qPCR for markers related to inflammasome and epigenetic patterns.
Statistical analyses were performed using a significance level of 5%.
Fibroblasts from Grade C periodontitis patients exhibited higher AIM2 levels compared to healthy individuals (p < 0.05).
IL-10 expression was lower in periodontitis fibroblasts before stimulation (p < 0.05).
After exposure, NLRP3 expression increased in healthy cells but remained unchanged in periodontitis cells (p < 0.05).

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Implication

Evaluates inflammasome gene expression in periodontitis, suggesting altered immune regulation.

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Cite This Study

Reis et al. (2026) studied this question.

synapsesocial.com/papers/6a65a337d3aea3239cd766f1 https://doi.org/10.1007/s00784-026-07040-1

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