Exosome-Laden 3D Composite Mesh Attenuates Stress Concentration and Promotes Collagen Regeneration toward Pelvic Organ Prolapse Repair

. It actively modulated the repair microenvironment, leading to a rapidly resolved inflammatory response, reduced macrophage infiltration, enhanced myofibroblast activation, and orderly collagen remodeling with a significant increase in collagen type III. Transcriptomic analysis revealed that the mesh induces a systemic anti-inflammatory and pro-repair molecular phenotype. In summary, this work achieves a strategic shift from passive support to active regeneration through synergistic mechanical and biological design, offering a promising direction toward next-generation pelvic floor repair.