Enantioselective Access to Taxodione

Vitalii S. Basistyi; Kyle J. Parella; Svetlana N Kononenko; Zachary Deal; James H. Frederich

doi:10.1055/a-2922-6685

July 23, 2026Synthesis

Enantioselective Access to Taxodione

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Key Points

The aim is to present a method for the enantioselective synthesis of taxodione for its distinct effects in glioblastoma.
Developed a synthesis pathway for taxodione using quinone methide strategy.
Characterized the profiles of (+)-taxodine and (-)-taxodone in vitro.
Assessed the effects on glioblastoma cell cultures.
Introduced new access methods to taxodione with high enantioselectivity.
Demonstrated significant differences between (+)-taxodine and (-)-taxodone profiles in glioblastoma.
Highlighted potential implications for targeted therapies in glioblastoma.

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Implication

Enantioselective approach develops taxodione in glioblastoma treatments, indicating potential therapeutic benefits.

Abstract

A concise and enantioselective entry point to the quinone methide diterpene taxodione is presented. This synthesis was motivated by the distinct profiles of (+)-taxodine and (-)-taxodone in glioblastoma cell culture, which are delineated here for the first time.

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Basistyi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a36cd3aea3239cd7694a https://doi.org/10.1055/a-2922-6685

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Enantioselective Access to Taxodione

Key Points

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Implication

Abstract

Discussion

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Enantioselective Access to Taxodione

Key Points

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Implication

Abstract

Discussion

Cite This Study

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