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July 26, 2026Annals of Hepato-Biliary-Pancreatic SurgeryOpen Access

Pre-operative neutrophil-to-lymphocyte ratio significantly predicts local recurrence in pancreatic ductal adenocarcinoma

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Authors

ASAlwin Puthiyakunnel SajiBVBhamini VadhwanaMBManaal Bharadia

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Overview

Retrospective analysis finds that pre-operative NLR predicts recurrence in pancreatic ductal adenocarcinoma, suggesting its use in risk assessment.

Key Points

  • To investigate the effect of pre-operative neutrophil-to-lymphocyte ratio (NLR) on post-operative recurrence of pancreatic ductal adenocarcinoma (PDAC).
  • Retrospective analysis of patients undergoing surgery for PDAC between 2015 and 2024.
  • Patients categorized into high and low NLR groups using a threshold of 3.
  • Comparative analysis through receiver operating characteristic curves and Cox regression models.
  • High NLR group showed a higher recurrence rate (62.3% vs. 31.9%, p = 0.002).
  • Local recurrence significantly greater in high NLR group (43.4% vs. 19.4%, p = 0.004).
  • High NLR remained a significant predictor of recurrence (HR 2.540, p < 0.001 for univariable; HR 2.817, p < 0.001 for multivariable analysis.

Cite This Study

Saji et al. (2026) studied this question.

synapsesocial.com/papers/6a65a3a3d3aea3239cd76a0chttps://doi.org/10.14701/ahbps.26-101
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