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July 26, 2026Journal of Cardiothoracic SurgeryOpen Access

Identification and validation of brown adipocyte-related key genes in ST-segment elevated myocardial infarction

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Key result

A 3-gene nomogram model demonstrates excellent diagnostic performance for STEMI with an AUC of ~0.97.

  • AUC 0.973
  • n=10

Why the study?

STEMI involves complex molecular mechanisms potentially linked to brown adipocyte biology, but the specific brown adipocyte-related key genes and their roles in STEMI progression remain to be identified.

Population

STEMI patients and stable CAD controls from GEO datasets plus an independent clinical cohort of n = 5 per group

Comparison

STEMI vs stable CAD controls

Design

Bioinformatic transcriptomic analysis and machine learning study with RT-qPCR clinical cohort validation

Authors

HLHui LiXCX Z ChenCMChanghui Ma

Discussion

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Overview

BA-related gene signatures may aid STEMI biomarker discovery; leaves open causal roles and clinical translation.

Key Points

  • This study aims to identify and validate key genes associated with brown adipocytes in ST-segment elevation myocardial infarction.
  • Transcriptomic data from STEMI patients and CAD controls were analyzed using limma and WGCNA.
  • Candidate genes identified through intersections of DEGs and module genes were refined using LASSO regression and SVM-RFE.
  • Independent RT-qPCR validation was conducted with a preliminary clinical cohort (n=5 per group).
  • Identified ASGR2, MCEMP1, and PPARG as key genes consistently upregulated in STEMI.
  • Nomogram model incorporating these genes achieved an AUC of 0.973 for diagnostic performance.
  • GSEA revealed enrichment in neutrophil degranulation and Toll-like receptor signaling pathways.

Study Design

Type

Observational (n=10)

Structured PICO

P
Population
Transcriptomic data from STEMI patients and stable CAD controls, with findings validated in an independent clinical cohort of 10 patients (5 per group).
E
Exposure
Bioinformatic identification and machine learning validation of brown adipocyte-related key genes (ASGR2, MCEMP1, PPARG)
C
Comparator
Stable coronary artery disease (CAD) controls
O
Outcome
Identification of key genes and diagnostic performance (AUC) for STEMIsurrogate

Main Result

Effect estimate: AUC 0.973

ASGR2, MCEMP1, and PPARG were identified as brown adipocyte-associated key genes upregulated in STEMI, showing excellent diagnostic potential and immune-metabolic relevance.

Cite This Study

Li et al. (2026) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=10). ST-segment elevation myocardial infarction (STEMI) vs. Stable coronary artery disease (CAD) was evaluated on Diagnostic performance of a 3-gene nomogram model (AUC 0.973). A nomogram model incorporating brown adipocyte-related genes ASGR2, MCEMP1, and PPARG demonstrated excellent diagnostic performance for STEMI, achieving an AUC of 0.973.

synapsesocial.com/papers/6a65a3a3d3aea3239cd76a66https://doi.org/10.1186/s13019-026-04649-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative transcriptomic analysis and experimental validation identify GPR97 and PROK2 as novel genes upregulated in acute myocardial infarction2026
  2. 2Integrated Gene Expression Profiling Analysis Reveals Potential Molecular Mechanisms and Candidate Biomarkers for Early Risk Stratification and Prediction of STEMI and Post-STEMI Heart Failure Patients2020 · 1 citations
  3. 3Integrated Multichip Analysis and WGCNA Identify Potential Diagnostic Markers in the Pathogenesis of ST‐Elevation Myocardial Infarction2022 · 4 citations
  4. 4Bioinformatics-based analysis of key genes associated with endoplasmic reticulum stress in myocardial infarction2026
  5. 5Identification of platelet function-related genes in STEMI patients2025