Key result
Eight upregulated genes including GPR97 and PROK2 detect AMI with an AUC >0.80.
Why the study?
Current diagnostic reliance on hs-cTn in AMI is limited by a lack of disease specificity and an inability to reveal upstream molecular and immune mechanisms.
Population
Three peripheral blood transcriptomic datasets from GEO and H9C2 cells under oxygen-glucose deprivation
Design
Integrated transcriptomic analysis and in vitro experimental validation study
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Does not support changing AMI diagnostics; leaves open validation of core gene networks as specific biomarkers.
Effect estimate: AUC > 0.80
p-value: p=<0.05
A 2026 study studied Acute myocardial infarction (n=47). Acute myocardial infarction vs. Healthy controls was evaluated on Diagnostic performance of core upregulated genes (AUC > 0.80, p=<0.05). Integrative transcriptomic analysis identified eight core genes, including novel genes GPR97 and PROK2, that were consistently upregulated in acute myocardial infarction with high diagnostic accuracy (AUC > 0.80).
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