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July 26, 2026Signal Transduction and Targeted TherapyOpen Access

Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma

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Authors

TXTongji XieLWLige WuYLYan Li

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Overview

Randomized trial reveals organ-specific metastasis risk models in lung adenocarcinoma, indicating new therapeutic insights.

Key Points

  • The aim is to explore the molecular mechanisms and develop risk models for distant metastasis in lung adenocarcinoma.
  • Integrated digital spatial profiling, multiplex immunofluorescence, and clinical data from 52 LUAD patients.
  • Developed organ-specific metastasis risk models using random forest models based on tumor spatial transcriptomics.
  • Conducted pathway analyses to identify biological processes associated with organotropism.
  • Random forest models achieved high precision in predicting brain (AUC = 0.974), liver (AUC = 0.975), adrenal gland (AUC = 0.929), and bone metastases (AUC = 0.907).
  • Identified key gene signatures linked to organ-specific metastasis, with distinct pathways such as cell death in brain and ECM remodeling in liver.
  • Postmetastasis survival models highlighted stromal gene expression and immunosuppressive factors as critical prognostic indicators.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/6a65a3e4d3aea3239cd76bdchttps://doi.org/10.1038/s41392-026-02817-y
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