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This review aims to provide an overview of cancer stem cells and their regulatory pathways, emphasizing the need for targeted therapies.

July 26, 2026Discover OncologyOpen Access

Targeting cancer stem cells: advances in small molecules, biologics, and immunotherapies

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Review highlights advances in small molecules and immunotherapies targeting cancer stem cells, indicating a promising direction for treatment.

This review aims to provide an overview of cancer stem cells and their regulatory pathways, emphasizing the need for targeted therapies.
Comprehensive review of the biology of cancer stem cells and their interactions with the tumor microenvironment.
Overview of major regulatory pathways and recent therapeutic advancements targeting cancer stem cells.
Cancer stem cells show significant heterogeneity and contribute to therapy resistance in cancer treatment.
Advancements in small molecules and biologics targeting cancer stem cells have been made, but challenges remain.

Debnath et al. (2026) studied this question.

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Review highlights advances in small molecules and immunotherapies targeting cancer stem cells, indicating a promising direction for treatment.