What question did this study set out to answer?

This research aims to address the challenges of stem cell collection in patients with cold agglutinins due to temperature sensitivity.

July 26, 2026Journal of Clinical ApheresisOpen Access

Temperature Safeguards and Peri‐Procedural Strategies for Stem Cell Collection in Cold Agglutinin Disease: A Case Report and Literature Review

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This research aims to address the challenges of stem cell collection in patients with cold agglutinins due to temperature sensitivity.
Case report of a 49-year-old man with cold agglutinins and multiple myeloma.
Utilized temperature mitigation strategies including environmental warming, insulation, and prewarmed equipment during stem cell collection.
Coordination between hematology, apheresis, and cell therapy teams to ensure efficient collection and processing.
5.61 × 10^6 CD34 + cells/kg collected without circuit alarms or visible agglutination.
Conditioning with high-dose melphalan and autologous infusion completed without complications.
Successful engraftment post-transplantation.

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Implication

Case report shows effective strategies for stem cell collection in a patient with cold agglutinin disease, highlighting multidisciplinary collaboration.

Cite This Study

Bellegarde et al. (2026) studied this question.

synapsesocial.com/papers/6a65a501d3aea3239cd774ad https://doi.org/10.1002/jca.70158

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Implication

Case report shows effective strategies for stem cell collection in a patient with cold agglutinin disease, highlighting multidisciplinary collaboration.

Temperature Safeguards and Peri‐Procedural Strategies for Stem Cell Collection in Cold Agglutinin Disease: A Case Report and Literature Review

Key Points

Discussion

Implication

Cite This Study

Temperature Safeguards and Peri‐Procedural Strategies for Stem Cell Collection in Cold Agglutinin Disease: A Case Report and Literature Review

Key Points

Discussion

Implication

Cite This Study

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