Key result
Filamin-A directly interacts with Kir2.1 in vascular smooth muscle cells, increasing the number of functional channels at the cell membrane without altering individual channel behavior.
No takes yet. Share an insight, caveat, or question.
May link filamin-A scaffolding to Kir2.1 vascular tone control; leaves open functional consequences in vivo.
Sampson et al. (2003) studied this question. Filamin-A interaction with Kir2.1 was evaluated on Interaction between filamin-A and Kir2.1 and its effect on channel behavior. Filamin-A directly interacts with Kir2.1 in vascular smooth muscle cells, increasing the number of functional channels at the cell membrane without altering individual channel behavior.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: