Key result
Individuals with bipolar disorder are differentially affected by stress-sensitive medical disorders, notably circulatory disorders, obesity, and diabetes mellitus.
Somatic health issues in individuals with bipolar disorder are ubiquitous, under-recognized, and suboptimally treated, highlighting the need for routine screening and behavioral modification.
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Supports monitoring for cardiovascular comorbidity in bipolar patients; leaves open optimal screening and causal pathways.
PURPOSE OF REVIEW: The aim of this review is to synthesize results from extant investigations which report on the co-occurrence of bipolar disorder and medical comorbidity. RECENT FINDINGS: We conducted a MEDLINE search of all English-language articles published between January 2004 and November 2006. Most studies report on medical comorbidity in bipolar samples; relatively fewer studies report the reciprocal association. Individuals with bipolar disorder are differentially affected by several 'stress-sensitive' medical disorders notably circulatory disorders, obesity and diabetes mellitus. Neurological disorders (e.g. migraine), respiratory disorders and infectious diseases are also prevalent. Although relatively few studies have scrutinized the co-occurrence of bipolar disorder in medical settings, individuals with epilepsy, multiple sclerosis, migraine and circulatory disorders may have a higher prevalence of bipolar disorder. A clustering of traditional and emerging (e.g. immuno-inflammatory activation) risk factors presage somatic health issues in the bipolar disorder population. Iatrogenic factors and insufficient access to primary, preventive and integrated healthcare systems are also contributory. SUMMARY: Somatic health issues in individuals with bipolar disorder are ubiquitous, under-recognized and suboptimally treated. Facile screening for risk factors and laboratory abnormalities along with behavioral modification for reducing medical comorbidity are warranted.
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McIntyre et al. (2007) conducted a review in Bipolar disorder and medical comorbidity. Bipolar disorder was evaluated on Co-occurrence of bipolar disorder and medical comorbidity. Individuals with bipolar disorder are differentially affected by stress-sensitive medical disorders, notably circulatory disorders, obesity, and diabetes mellitus.
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