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July 26, 2026iScienceOpen Access

GSK3B variations influence renoprotective responses to dapagliflozin in diabetic kidney disease

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Authors

JSJinfang SongYXY XuYZYongru Zhuang

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Overview

Randomized trial shows GSK3B polymorphisms influence renal response to dapagliflozin in T2DKD, suggesting targeted interventions.

Key Points

  • To explore how variations in GSK3B influence renoprotective responses to dapagliflozin in patients with diabetic kidney disease.
  • Conducted a retrospective clinical analysis to assess dapagliflozin's effects on urinary protein levels.
  • Utilized drug affinity responsive target stability (DARTS) and quantitative proteomics for target identification.
  • Performed a prospective trial examining the association of GSK3B polymorphism rs60393216 with UACR reduction.
  • Dapagliflozin significantly reduced urinary albumin-to-creatinine ratio (UACR) in participants with the GSK3B rs60393216 polymorphism.
  • In vitro studies showed that dapagliflozin partially inhibited GSK3β, enhancing podocyte protection.
  • Marked variability in dapagliflozin's efficacy was observed based on individual GSK3B genetic variations.

Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/6a65a5bad3aea3239cd77878https://doi.org/10.1016/j.isci.2026.116862
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  1. 1#150 Effect of dapagliflozin in patients with CKD depending on primary kidney disease2024
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  4. 4Reduction in Albuminuria with Dapagliflozin Exhibits Substantial Interindividual Variability: A Real-World Study Utilizing a Big Data Approach2026
  5. 5The redox-sensitive GSK3β is a key regulator of glomerular podocyte injury in type 2 diabetic kidney disease2024 · 44 citations