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This study aims to design a Type-I photosensitizer for effective breast cancer therapy via pyroptosis.

A Mitochondria-Targeted Iridium(III) Complex as a Potent Type-I/II Photosensitizer for Pyroptosis-Based Breast Cancer Therapy

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This study aims to design a Type-I photosensitizer for effective breast cancer therapy via pyroptosis.
Developed Mito-Ir, an iridium(III) complex for mitochondria targeting and reactive oxygen species generation.
Examined the activation of the caspase-3/GSDME pathway leading to pyroptosis upon light irradiation.
Conducted both in vitro and in vivo experiments to assess antitumor efficacy.
Mito-Ir induced pronounced pyroptosis by disrupting mitochondrial function, activating the caspase-3/GSDME pathway.
The therapy elicited immunogenic cell death, resulting in increased cytokine release and improved antitumor immunity.
Demonstrated significant antitumor effect, highlighting its potential for breast cancer treatment.

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Randomized trial demonstrates potent antitumor efficacy in breast cancer, suggesting a novel treatment approach.

Wei et al. (2026) studied this question.

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