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July 26, 2026PLoS neglected tropical diseasesOpen Access

Safety and operational feasibility of single versus cocktail rabies monoclonal antibodies for post-exposure prophylaxis in a resource-limited setting

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This study aims to compare the safety, ease of administration, and operational feasibility of single versus cocktail rabies monoclonal antibodies (mAbs) for post-exposure prophylaxis.
Conducted in a rabies PEP clinic in India from October 2021 to December 2022.
159 patients received single mAb (Rabishield) and 159 received two-mAb cocktail (Twinrab) with vaccination.
Data analyzed using t-tests and chi-square or Fisher's exact tests for significance.
Rabishield required more vials per patient (2.28 vs 2.00; p = 0.001) and a higher infiltration volume (4.7 mL vs 4.0 mL; p < 0.001).
Local adverse events were low; pain in 2.5% (Rabishield) vs 7.5% (Twinrab; p = 0.07).
Both treatments were considered safe and operationally feasible in a high-volume clinic setting.

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Comparative observational study evaluates safety and efficacy of single versus cocktail rabies mAbs, highlighting implications for resource-limited settings.

Cite This Study

Fotedar et al. (2026) studied this question.

synapsesocial.com/papers/6a65a5bad3aea3239cd778a3 https://doi.org/10.1371/journal.pntd.0014274

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Implication

Comparative observational study evaluates safety and efficacy of single versus cocktail rabies mAbs, highlighting implications for resource-limited settings.

Safety and operational feasibility of single versus cocktail rabies monoclonal antibodies for post-exposure prophylaxis in a resource-limited setting

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Discussion

Implication

Cite This Study

Safety and operational feasibility of single versus cocktail rabies monoclonal antibodies for post-exposure prophylaxis in a resource-limited setting

Key Points

Discussion

Implication

Cite This Study

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