Efficacy and limitations of diffusion-weighted imaging with background suppression-based whole-body magnetic resonance imaging in high-risk prostate cancer staging: A retrospective study

July 23, 2026PLoS ONEOpen Access

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Key Points

This study aims to evaluate the performance of whole-body MRI using diffusion-weighted imaging in staging high-risk prostate cancer.
Retrospective analysis of 38 patients with newly diagnosed high-risk prostate cancer.
Comparison of DWIBS with CT and bone scintigraphy for staging, using extended pelvic lymph node dissection as the reference standard in 14 patients.
Imaging performed within two months prior to treatment initiation.
Both DWIBS and CT showed 64.3% sensitivity and 100.0% specificity for lymph node metastases.
DWIBS demonstrated 88.9% sensitivity and 100.0% specificity for bone metastases compared to BS, which had 100.0% sensitivity and 96.6% specificity.
DWIBS detected fewer lung metastases than chest CT, confirming two out of three cases on coronal T2-weighted images.

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Retrospective study evaluates DWIBS for staging prostate cancer, suggesting it as a feasible alternative imaging strategy.

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Nakajima et al. (2026) studied this question.

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