What question did this study set out to answer?

The aim is to identify viable synthetic routes by exploiting underutilized side pathways in chemical reactions.

Identifying viable synthetic routes from side channels in automated reaction-path searches

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Randomized trial demonstrates potential of network editing to discover novel synthetic pathways.

The aim is to identify viable synthetic routes by exploiting underutilized side pathways in chemical reactions.
Proposed a network editing strategy to remove kinetically dominant pathways from reaction networks.
Performed kinetic simulations on the edited networks to identify masked side reactions.
Applied the strategy to develop synthetic routes for N-allylaniline derivatives.
Demonstrated successful arylcarboxylation of N-allylaniline derivatives via CO2 radical anion.
Accessed five- and six-membered N-heterocycles through this novel synthetic route.
Highlighting the effectiveness of computational tools in advancing synthetic organic chemistry.

Ueno et al. (2026) studied this question.

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