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July 26, 2026Exploration of Targeted Anti-tumor TherapyOpen Access

Reactive oxygen species (ROS) in cancer: from redox signaling and metabolic plasticity to therapeutic vulnerabilities

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Authors

TUTaslim UddinTKTajmin KhanamAAAfia Asma

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Overview

Review discusses ROS roles in cancer, therapeutic challenges, and strategies to leverage tumor-specific vulnerabilities.

Key Points

  • To explore the roles of ROS in cancer biology and analyze therapeutic vulnerabilities associated with redox adaptation.
  • Critical analysis of molecular functions of ROS in tumor biology.
  • Discussion of redox-targeted therapeutic strategies and their clinical challenges.
  • Review of emerging evidence on ferroptosis and its implications in redox-adapted tumors.
  • Intra-tumoral heterogeneity affects redox status and treatment response.
  • Ferroptosis emerges as a therapeutic target in redox-adapted tumors, particularly when antioxidant systems are compromised.
  • Clinical translation of ROS-targeted therapies remains problematic, with many trials failing or increasing cancer risk.

Cite This Study

Uddin et al. (2026) studied this question.

synapsesocial.com/papers/6a65a660d3aea3239cd77ce0https://doi.org/10.37349/etat.2026.1002383
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