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This is a Cohort Study study (also classified as: Experimental Study).

September 30, 2025AntioxidantsOpen Access

The Redox Paradox: Cancer’s Double-Edged Sword for Malignancy and Therapy

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Observation reveals targeting redox pathways can disrupt cancer survival in malignancy, suggesting new therapies.

High levels of reactive oxygen species promote cancer progression, but targeting antioxidant systems may induce cancer cell death.
Therapies like high-dose vitamin C and arsenic trioxide show tumor-selective toxicity, presenting a promising treatment avenue.
Inhibiting Nrf2 or disrupting glutathione systems can induce ferroptosis, a form of cell death valuable for targeting cancer cells.
Redox-active metal complexes offer innovative strategies by exploiting the differential redox state in cancer therapy.

Ranbhise et al. (2025) studied this question.

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