What question did this study set out to answer?

This review aims to explore how pH regulation impacts tumor biology and immune response, identifying potential therapeutic avenues and challenges.

July 26, 2026APOPTOSISOpen Access

Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges

View Full Paper

Ask AI

Bookmark

Authors

Review summarizes pH regulation mechanisms in cancer, highlighting therapeutic strategies and implications for immune response.

This review aims to explore how pH regulation impacts tumor biology and immune response, identifying potential therapeutic avenues and challenges.
Summarized recent advances in pH regulation and its effects on cancer and immunity.
Evaluated alkalization-related interventions and their context-dependent outcomes.
Discussed quantitative measurement techniques for pH in various tumor compartments.
Modulation of pH across the tumor environment can trigger regulated cell death and improve immune function.
Alkalization strategies may suppress tumor growth but could also have neutral or protumorigenic effects based on tumor characteristics.
Highlighted translational barriers that hinder the clinical application of pH modulation.

Chen et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark