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Shows improved outcomes in Reynolds Syndrome through early screening and therapy.
Reynolds Syndrome should be suspected in CREST patients with persistent cholestatic liver enzymes, since delayed diagnosis allows portal hypertension and variceal bleeding to develop. Early anti‐mitochondrial antibody screening and prompt ursodeoxycholic acid therapy improve outcomes, and these patients need multidisciplinary follow‐up for lung and thyroid disease.
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Gohar et al. (2026) studied this question.
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