Overlap of Primary Biliary Cholangitis and Systemic Sclerosis: A Case of Reynolds Syndrome

Key Points

• This research aims to identify symptoms of Reynolds Syndrome in patients with CREST syndrome and improve early diagnosis and treatment.
• Screening for anti-mitochondrial antibodies in CREST patients with cholestatic liver enzymes.
• Administering ursodeoxycholic acid therapy to affected patients.
• Implementing multidisciplinary follow-up for associated lung and thyroid disease.
• Early treatment with ursodeoxycholic acid significantly reduces the risk of portal hypertension (RR not specified).
• Patients with prompt anti-mitochondrial antibody screening showed better health outcomes (specific metrics not detailed).
• Delayed diagnosis was linked to a higher incidence of variceal bleeding.