ABSTRACT Extending photocatalysis into living systems is hindered by the tissue penetration of ultraviolet (UV)/visible light. We herein report a novel near‐infrared (NIR) photocatalyst, constructed by conjugating a Pt(II) porphyrin with a cyanine dye. Upon 808 nm irradiation, it operates via dual energy/electron‐transfer pathways to simultaneously generate reactive oxygen species ( 1 O 2 , O 2 · − , ·OH) and oxidize the metabolic cofactor NADH. This dual action disrupts redox balance and induces immunogenic cell death. Delivered as biocompatible nanoparticles, the system enables precise tumor delineation by fluorescence (FL)/photoacoustic (PA) imaging, and proceeds by activating tumor‐specific cytotoxic T cells, thus impeding both primary and distant tumor progression to achieve high therapeutic efficiency. This work establishes an NIR photocatalytic strategy for synergistic cancer therapy.
Zhang et al. (Fri,) studied this question.