PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
July 26, 2026Turkish Journal of BiochemistryOpen Access

Dynamics of neutrophil-to-lymphocyte ratio and disability status during an acute relapse and corticosteroid therapy in relapsing-remitting multiple sclerosis

View Full Paper
Ask AI
Bookmark
Share

Authors

CACanan AkçinSMSemra MunganBABuse Aydın

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates inflammatory markers and disability in relapsing-remitting multiple sclerosis, suggesting new monitoring strategies.

Key Points

  • This study aims to understand how the neutrophil-to-lymphocyte ratio (NLR) changes during relapses and corticosteroid treatment in relapsing-remitting multiple sclerosis.
  • Included 20 patients with relapsing-remitting multiple sclerosis relapses and 60 healthy controls.
  • Blood samples collected at three time points: before treatment, end of treatment, and one month later.
  • Analyzed NLR and disability scores using statistical methods, including repeated-measures correlation.
  • NLR was significantly higher before corticosteroid therapy compared to controls (p=0.009) and increased further at the end of treatment (p<0.001).
  • EDSS scores significantly decreased at the end of treatment and remained lower one month after therapy.
  • Moderate discrimination for NLR as a biomarker was observed, with AUC values of 0.696 (BT vs. controls) and 0.727 (ET vs. BT).

Cite This Study

Akçin et al. (2026) studied this question.

synapsesocial.com/papers/6a65a7b4d3aea3239cd786a0https://doi.org/10.1515/tjb-2025-0528
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal Changes in Neutrophil-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios During Multiple Sclerosis Relapse2026
  2. 2Neutrophil-to-Lymphocyte Ratio, ESR, and CRP Have No Roles as Markers for Disease Severity and Prognosis in Patients with RRMS2024 · 2 citations
  3. 3Analysis of the value of NLR, MLR and PLR levels in peripheral blood of patients with RRMS2024
  4. 4Neutrophil/lymphocyte ratio as an indicator of radiological disease activity in clinically stable multiple sclerosis2024 · 1 citations
  5. 5Evaluation of hematological markers and disease activity in relapsing-remitting multiple sclerosis2024