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June 13, 2026Journal of Clinical MedicineOpen Access

Longitudinal Changes in Neutrophil-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios During Multiple Sclerosis Relapse

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Authors

MKMarta KoniecznaPPPrzemysław PuzMGMichał Gałuszewski

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Overview

Retrospective study evaluates immune ratios during MS relapse vs. relapse-free controls, implying their potential role in inflammation.

Key Points

  • This study aims to assess how neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios change in multiple sclerosis patients during relapses.
  • Retrospective observational study at a single center over 2 years.
  • Included 34 MS patients with relapse and 68 matched controls without relapse.
  • Assessed NLR and MLR at three time points: pre-relapse, during relapse, and post-relapse.
  • During relapse, patients had higher NLR (2.75 to 3.62, p = 0.0002) and MLR (0.45 to 0.54, p = 0.002) compared to controls.
  • Control group showed no significant changes in NLR and MLR.
  • NLR and MLR declined after relapse, indicating dynamic changes in these immune markers.

Cite This Study

Konieczna et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056b45https://doi.org/10.3390/jcm15124539
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