What question did this study set out to answer?

This review aims to summarize the evidence on immunological biomarkers associated with outcomes in early-stage non-small cell lung cancer treated with SBRT.

July 26, 2026EClinicalMedicineOpen Access

Immunological biomarkers for precision stereotactic body radiation therapy in early-stage non-small cell lung cancer: a systematic review

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SVStefania VolpeUniversity of Milan LSLee SwHong Kong Polytechnic University MBMateusz BilskiMedical University of Lublin

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Systematic review highlights prognostic biomarkers for early-stage NSCLC treated with SBRT, suggesting need for larger studies.

Key Points

This review aims to summarize the evidence on immunological biomarkers associated with outcomes in early-stage non-small cell lung cancer treated with SBRT.
Systematic review of ten studies published in English, screened from PubMed/MEDLINE, Scopus, Embase, and ClinicalTrials.gov until November 30, 2025.
Included studies examined the association between immunological biomarkers and oncological outcomes in patients receiving SBRT.
Risk of bias was assessed using the Newcastle-Ottawa Scale, resulting in moderate-to-high methodological quality overall.
Elevated neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were consistently linked with poorer survival.
CD44 was identified as a potential predictive biomarker for recurrence risk after SBRT in an external cohort.
Prognostic signatures from immune profiling—including PD-1+ and CD4 T cells—were found, but these did not predict SBRT response.

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Volpe et al. (2026) studied this question.

synapsesocial.com/papers/6a65a7e0d3aea3239cd788ca https://doi.org/10.1016/j.eclinm.2026.104095

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Immunological biomarkers for precision stereotactic body radiation therapy in early-stage non-small cell lung cancer: a systematic review

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Cite This Study

Immunological biomarkers for precision stereotactic body radiation therapy in early-stage non-small cell lung cancer: a systematic review

Discussion

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Key Points

Cite This Study

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