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This study aims to assess the feasibility and safety of a modified CIAT protocol with continuous theta burst stimulation in a Greek clinical context.

July 26, 2026Brain SciencesOpen Access

Transcranial Magnetic Stimulation (TMS) Plus Modified Constraint-Induced Aphasia Therapy (mCIAT): A Pilot Feasibility Study with Sham and Real cTBS in Two Cases of Chronic Anomia–Protocol Deliverability and Greek Adaptation of mCIAT

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Pilot feasibility trial evaluates language recovery interventions in chronic anomia, indicating protocol safety and challenges.

This study aims to assess the feasibility and safety of a modified CIAT protocol with continuous theta burst stimulation in a Greek clinical context.
Single-subject experimental design for two participants with chronic anomic aphasia.
10-day treatment protocol; one received sham cTBS and mCIAT, while the other received real cTBS and mCIAT.
Language, cognitive, and QoL measures were administered across three baselines and two follow-up points.
Both participants completed the protocol with 100% adherence and no adverse effects, demonstrating feasibility.
No improvements in standardized expressive language measures were observed for either participant post-treatment.
One participant showed QoL improvement at the two-year follow-up, though findings require cautious interpretation.

Georgiou et al. (2026) studied this question.

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