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This study investigates two novel Pediococcus strains to assess their potential probiotic properties and metabolic regulation.

July 26, 2026MicroorganismsOpen Access

Integrated Genomics and Phenotypic Analysis of Pediococcus pentosaceus BGI-N8 and Pediococcus acidilactici BGI-N9: Partial Evidence Suggesting In Vitro Probiotic Properties to Glycolipid Metabolism Regulation Potential

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This study investigates two novel Pediococcus strains to assess their potential probiotic properties and metabolic regulation.
Integrated genome-phenotype approach utilizing whole-genome sequencing and in vitro assays.
Assessment of gastrointestinal tolerance, adhesion, and metabolic enzyme activity in bacterial strains.
Analysis of genomic safety and functional genotypes without high-confidence AMR determinants.
BGI-N9 exhibited superior acid resistance with 79.3% survival at pH 2.0.
Both strains showed significant auto-aggregation (>70%) and high adhesion to HT-29 cells (5.4 to 5.9 adherent bacteria per cell).
Inhibition rates for α-glucosidase activity were 44.53% for BGI-N8 and 39.94% for BGI-N9, with removal rates of 68.76% and 74.49% for cholesterol, respectively.

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Randomized trial evaluates metabolic regulation in obesity using probiotic strains, hinting at health benefits.

Ma et al. (2026) studied this question.

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