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This review aims to synthesize existing literature on the relationship between aluminum exposure and Alzheimer’s disease.

July 26, 2026NeuroToxicologyOpen Access

Aluminum and Alzheimer’s disease in the 21st century: An umbrella review of evidence and controversies

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Umbrella review examines aluminum's link to Alzheimer's disease, suggesting a contributory role in susceptible individuals.

This review aims to synthesize existing literature on the relationship between aluminum exposure and Alzheimer’s disease.
Conducted an umbrella review integrating reviews published from January 1, 2000, to May 2, 2026.
Prioritized systematic, meta-analytic, and epidemiological studies directly addressing aluminum and Alzheimer’s disease.
Appraised the methodological quality of included reviews and graded the strength of evidence.
Aluminum exposure supports pathways related to Alzheimer’s disease such as oxidative stress (strong evidence) and neuroinflammation (moderate evidence).
Epidemiological findings show some association between chronic aluminum exposure and cognitive decline, but evidence quality varies.
Overall, aluminum is not identified as the main cause of Alzheimer’s disease but is thought to play a contributory role.

Domingo et al. (2026) studied this question.

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