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July 26, 2026Cancer Prevention ResearchOpen Access

TP53-mutated preneoplastic colonies, adaptive immune response, and risk for lung cancer and COPD

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Authors

JWJames C. WilleyABAndrew BoringECErin L. Crawford

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Overview

Randomized trial assesses TP53-mutated colonies in airway epithelium, indicating risk for lung cancer and COPD.

Key Points

  • This study aims to characterize the prevalence and size distributions of TP53-mutated preneoplastic colonies and their relationship to lung cancer and COPD risk.
  • Analyzed specimens from 59 heavy smokers in four cohorts: lung cancer with/without COPD and non-lung cancer with/without COPD.
  • Used ultra-sensitive next-generation sequencing to assess TP53-mutated colonies comprising as few as 100 cells.
  • Evaluated prevalence and size distributions of colonies in relation to lung cancer and COPD.
  • TP53-mutated preneoplastic colonies were more prevalent in lung cancer and COPD subjects (P<0.01).
  • Larger colony sizes were observed among lung cancer subjects, particularly in those with COPD and active smoking (P<0.01).
  • Significant prevalence of colonies driven by neoantigenic TP53 mutations was noted (P<0.05).

Cite This Study

Willey et al. (2026) studied this question.

synapsesocial.com/papers/6a65a825d3aea3239cd78a79https://doi.org/10.1158/1940-6207.capr-26-0112
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2528: Effect of COPD diagnosis on TP53-mutated colony size distribution in airway epithelium of subjects with or without lung cancer2026
  2. 2Abstract 2542: Assessing the TP53 mutation prevalence biomarker for lung cancer in subjects without COPD2026
  3. 3B21-03 Chronic Obstructive Pulmonary Disease (COPD) Increases Propagation of Lung Cancer by Reducing the Cytotoxicity of Neutrophils to Tumor Cells2026
  4. 4Abstract 4781: Evaluation of a TP53 biomarker for lung cancer risk in nasal brushings and peripheral blood2024
  5. 5Characterization of <i>TP53</i> mutations in actionable driver-negative non-small cell lung cancer (NSCLC).2024 · 4 citations