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July 26, 2026CureusOpen Access

Modern Management of Complex Regional Pain Syndrome: A Practical Evidence-Based Review for Hand and Upper Extremity Surgeons

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Authors

MFMichael J. Franco

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Overview

Evidence-based review highlights treatment and diagnosis strategies for complex regional pain syndrome in upper extremity care.

Key Points

  • This review aims to consolidate current knowledge on the management and diagnosis of Complex Regional Pain Syndrome (CRPS) for hand and upper-extremity surgeons.
  • Synthesized 22 full-text publications identified through a PRISMA-style screening of 1,471 PubMed records.
  • Focused on multidisciplinary, function-centered treatment strategies and diagnostic frameworks.
  • Emphasized early interventions like patient education, desensitization, and coordinated care.
  • A multidisciplinary approach is favored, restoring limb function as the main therapeutic goal.
  • Current pharmacologic interventions vary in evidence certainty, but include corticosteroids and neuropathic pain medications.
  • Prompt diagnosis and exclusion of other conditions are crucial to improve patient outcomes.

Cite This Study

Michael J. Franco (2026) studied this question.

synapsesocial.com/papers/6a65a84ed3aea3239cd78c69https://doi.org/10.7759/cureus.113271
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Analgesic Efficacy of Therapies Used for Complex Regional Pain Syndrome: A Systematic Review2025
  2. 2Challenges in Diagnosis and Management of Complex Regional Pain Syndrome: Insights From a Retrospective 9-Year Review in an Academic Medical Center2025
  3. 3Complex Regional Pain Syndrome in a Non-traumatic Case: A Case Report2024 · 1 citations
  4. 4Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review2026
  5. 5Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy)2002 · 136 citations