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September 10, 2025CureusOpen Access

The Analgesic Efficacy of Therapies Used for Complex Regional Pain Syndrome: A Systematic Review

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Authors

CSCharlotte ShekarsaraiNMNicholas A McQuibbanNGNicola Gullick

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Overview

Systematic review evaluates analgesic efficacy of therapies for complex regional pain syndrome, indicating diverse treatment options.

Key Points

  • Significant pain reduction observed with bisphosphonates and ketamine in treating complex regional pain syndrome.
  • Analgesic therapies included both pharmacological and non-pharmacological approaches, showing varied efficacy.
  • Many trials were limited by small sample sizes or methodological flaws, highlighting challenges in treatment consistency.
  • There is a critical need for high-quality randomized controlled trials to improve long-term management of complex regional pain syndrome.

Cite This Study

Shekarsarai et al. (2025) studied this question.

synapsesocial.com/papers/68c193e99b7b07f3a0617c55https://doi.org/10.7759/cureus.91697
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review2026
  2. 2Tailoring Treatment in Complex Regional Pain Syndrome: A Comparative Study of Therapeutic Approaches in Complex Rehabilitation2025
  3. 3Neurocognitive Interventions Informed by Cognitive–Behavioral Therapy (CBT) Principles and Physical Exercise for Complex Regional Pain Syndrome: A Systematic Review2025
  4. 4Modern Management of Complex Regional Pain Syndrome: A Practical Evidence-Based Review for Hand and Upper Extremity Surgeons2026
  5. 5Efficacy of an intensive multimodal rehabilitation program in adult patients affected by complex regional pain syndrome type 1 (CRPS 1): a randomized controlled trial2024 · 1 citations