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September 14, 2026Pain Practice

Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review

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Authors

DDDanilo DonatiLDLucia D’AuriaVRVincenzo Ricci

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Overview

Comprehensive review reveals gabapentin and physical therapy show greatest efficacy in complex regional pain syndrome, highlighting the need for individualized, multimodal care.

Key Points

  • To summarize current pharmacological and non-pharmacological therapeutic strategies for managing neuropathic pain across complex regional pain syndrome Types I and II.
  • Searched Scopus, PubMed, Cochrane Library, and Google Scholar for randomized controlled trials, meta-analyses, case series, and case reports evaluating complex regional pain syndrome management.
  • Categorized interventions into pharmacological and non-pharmacological modalities while evaluating therapeutic response differences between Type I and Type II subtypes.
  • Gabapentin demonstrated the strongest evidence among pharmacological options (Level 1 evidence), and physiotherapy showed the strongest support among non-pharmacological options (Level 2 evidence).
  • Evidence remains limited or inconsistent for alternative therapies, including non-gabapentin anticonvulsants, antidepressants, opioids, ketamine, botulinum toxin, mirror therapy, acupuncture, and spinal cord stimulation.
  • Therapeutic efficacy did not differ significantly between complex regional pain syndrome Type I and Type II.

Cite This Study

Donati et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b26d0926e14a848b0e30https://doi.org/10.1111/papr.70197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Analgesic Efficacy of Therapies Used for Complex Regional Pain Syndrome: A Systematic Review2025
  2. 2Modern Management of Complex Regional Pain Syndrome: A Practical Evidence-Based Review for Hand and Upper Extremity Surgeons2026
  3. 3Tailoring Treatment in Complex Regional Pain Syndrome: A Comparative Study of Therapeutic Approaches in Complex Rehabilitation2025
  4. 4A Systematic Critical Appraisal of Clinical Practice Guidelines for Non‐Pharmacological Conservative Management of Complex Regional Pain Syndrome (CRPS) Using the AGREE‐II Instrument2026
  5. 5Neurocognitive Interventions Informed by Cognitive–Behavioral Therapy (CBT) Principles and Physical Exercise for Complex Regional Pain Syndrome: A Systematic Review2025