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July 26, 2026BiologyOpen Access

Integrated Transcriptomic and Metabolomic Analysis Reveals the Regulatory Mechanisms of Macrobrachium rosenbergii in Response to Acute High-Salinity Stress

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Authors

YXYan XiaZLZ Y LiXSXudong Shen

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Overview

Integrated analysis reveals metabolic and genetic responses to acute salinity stress in freshwater crustaceans, indicating adaptation strategies.

Key Points

  • The aim was to investigate the regulatory mechanisms employed by Macrobrachium rosenbergii in response to acute high-salinity stress.
  • An integrated transcriptomic and metabolomic approach was used to analyze samples from the hepatopancreas of M. rosenbergii.
  • Differentially expressed genes and metabolites were quantified at 24 and 48 hours post-exposure to high salinity (20‰).
  • Pathway analysis was performed to identify metabolic shifts and regulatory networks activated during stress response.
  • A total increase in differentially expressed genes and metabolites was observed from 24 to 48 hours, indicating a transition in stress response.
  • Significant activation of autophagy and reprogramming of lipid and nucleotide metabolism were identified.
  • The glutamate dehydrogenase gene was downregulated while L-glutamate accumulated, suggesting a transcriptional-metabolic decoupling in the stress response.

Cite This Study

Xia et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78defhttps://doi.org/10.3390/biology15151234
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation and Response Mechanism of Acute Low-Salinity Stress during Larval Stages in Macrobrachium rosenbergii Based on Multi-Omics Analysis2024 · 6 citations
  2. 2Integrated miRNA-mRNA transcriptomic analysis of hepatopancreas reveals molecular mechanisms in Macrobrachium rosenbergii under graded nitrite stress2026
  3. 3Influence of salinity on growth, nutrient utilization, and gene expression of giant freshwater prawn (Macrobrachium rosenbergii)2026
  4. 4Comparative Transcriptome Analysis of the Hepatopancreas from Macrobrachium rosenbergii Exposed to the Heavy Metal Copper2024 · 7 citations
  5. 5Low temperature stress induces tissue-specific metabolic reprogramming and mitochondrial injury in Macrobrachium rosenbergii: Insights from integrated transcriptomic and physiological analyses2026